Recent Publications

Michel, B., Sinha, A.K. and Leach, D.R.F. (2018).  Replication Fork Breakage and Restart in Escherichia coli. MMBR 82(3). pii: e00013-18. doi: 10.1128/MMBR.00013-18 Link to Pubmed

White, M.A., Azeroglu, B., Lopez-Vernaza, M.A., Hasan, A.M.M. and Leach, D.R.F. (2018) Nucleic Acids Res. doi: 10.1093/nar/gky463. Link to Pubmed

Amarh, V., White, M.A. and Leach, D.R.F. (2018).  Dynamics of RecA-mediated repair of replication-dependent DNA breaks. J. Cell Biol. 217(7):2299-2307. doi: 10.1083/jcb.201803020. Link to Pubmed

Sinha, A.K., Durand, A., Desfontaines, J.M., Iurchenko, I., Auger, H., Leach, D.R.F., Barre, F.X. and Michel, B. (2017) PLoS Genet. 13(10):e1006895. doi: 10.1371/journal.pgen.1006895. Link to Pubmed

Azeroglu, B. and Leach, D.R. (2017). RecG controls DNA amplification at double-strand breaks and arrested replication forks.  doi: 10.1002/1873-3468.12583. Link to Pubmed

Azeroglu, B., Mawer, J.S., Cockram, C.A., White, M.A., Hasan, A.M., Filatenkova, M. and Leach, D.R. (2016). RecG Directs DNA Synthesis during Double-Strand Break Repair. PLoS Genet. 12(2):e1005799. Link to Pubmed

Cockram, C.A., Filatenkova, M., Danos, V., El Karoui, M. and Leach, D.R. (2015). Quantitative genomic analysis of RecA protein binding during DNA double-strand break repair reveals RecBCD action in vivo. Proc Natl Acad Sci U S A. pii: 201424269. Link to Pubmed

Hasan, A.M. and Leach, D.R. (2015) Chromosomal directionality of DNA mismatch repair in Escherichia coli. Proc Natl Acad Sci U S A. 112(30):9388-93.  Link to Pubmed

Azeroglu, B., Lincker, F., White, M.A., Jain, D. and Leach, D.R. (2014). A perfect palindrome in the Escherichia coli chromosome forms DNA hairpins on both leading- and lagging-strands. Nucleic Acids Res. 42(21):13206-13. Link to Pubmed

Darmon, E., Eykelenboom, J.K., Lopez-Vernaza, M.A., White, M,A, and Leach, D.R. (2014). Repair on the Go: E. coli Maintains a High Proliferation Rate while Repairing a Chronic DNA Double-Strand Break.PLoS One 9(10):e110784. Link to Pubmed

Mawer, J.S. and Leach, D. R. (2014). Branch migration prevents DNA loss during double-strand break repair. PLoS Genet. 10(8):e1004485. Link to Pubmed

Jackson, A., Okely, E. A. and  Leach, D. R. (2014). Expansion of CAG repeats in Escherichia coli Is controlled by single-strand DNA exonucleases of both polarities. Genetics 198(2):509-17. Link to Pubmed

Darmon, E. and Leach, D. R. (2014). Bacterial genome instability. Microbiol Mol Biol Rev. 78(1):1-39. Link to Pubmed

Mawer, J. S. and Leach, D. R. (2013). Pulsed-field gel electrophoresis of bacterial chromosomes. Methods Mol Biol. 1054:187-94. Link to Pubmed

Lopez-Vernaza, M. A. and Leach D. R. (2013). Symmetries and asymmetries associated with non-random segregation of sister DNA strands in Escherichia coli. Semin Cell Dev Biol. 24(8-9): 610-7. Link to Pubmed

Michel, B. and Leach, D. (2012). Chapter 7.2.7. Homologous recombination‚€”enzymes and pathways. In Curtiss R III, Kaper JB, Squires CL, Karp PD, Neidhardt FC, Slauch JM (ed), EcoSal‚€”Escherichia coli and Salmonella: cellular and molecular biology. ASM Press, Washington, DC. 10.1128/ecosalplus.7.2.7.

Blackwood, J. K., Okely, E., Zahra, R., Eykelenboom, J. K. and Leach, D. R. F. (2010). DNA tandem repeat instability in the Escherichia coli chromosome is stimulated by mismatch repair at an adjacent CAG-CTG trinucleotide repeat. PNAS. 107(52): 22582-6. Link to Pubmed

Darmon, E., Eykelenboom, J. K., Lincker, F., Jones, L. H., Okely, E., Blackwood, J. K., White, M., and Leach, D. R. F. (2010). E. coli SbcCD and RecA control chromosomal rearrangement induced by an interrupted palindrome. Molecular Cell 39: 1-12. Link to Pubmed

Andreoni, F., Darmon, E., Poon W. C. and Leach, D. R. F. (2010). Overexpression of the single-stranded DNA-binding protein (SSB) stabilises CAG.CTG triplet repeats in an orientation dependent manner. FEBS Lett. 584: 153-158. Link to Pubmed

Wardrope, L., Okely, E. and Leach, D. R. F. (2009). Resolution of joint molecules by RuvABC and RecG following cleavage of the Escherichia coli chromosome by EcoKI. PLoS One 4(8): e6542. Link to Pubmed

White MA, Eykelenboom JK, Lopez-Vernaza MA, Wilson E and Leach DR (2008). Non-Random Segregation of Sister Chromosomes in Escherichia coli. Nature; 455(7217): 1248-1250 . Link to Pubmed

Eykelenboom JK, Blackwood JK, Okely E, and Leach DR (2008). SbcCD Causes a Double-Strand Break at a DNA Palindrome in the Escherichia coli Chromosome. Molecular Cell; 29(5): 644-651. Link to Pubmed

Darmon E, Lopez-Vernaza MA, Helness AC, Borking A, Wilson E, Thacker Z, Wardrope L, and Leach DR (2007). SbcCD Regulation and Localization in Escherichia coli. Journal of Bacteriology; 189(18): 6686-6694. Link to Pubmed

Zahra R, Blackwood JK, Sales J, and Leach DR (2007). Proofreading and Secondary Structure Processing Determine the Orientation Dependence of CAG.CTG Trinucleotide Repeat Instability in Escherichia coli. Genetics; 176(1): 27-41. Link to Pubmed

Jordan PW, Klein F, and Leach DR (2007). Novel Roles for Selected Genes in Meiotic DNA Processing. PLOS Genetics; 3(12): e222. Link to Pubmed

Leach, D. R. F. (2007). Holliday junctions, heteroduplex DNA and map expansion: a commentary on ‚€œa mechanism for gene conversion in fungi‚€� by Robin Holliday. Genet. Res. 89: 281-283. Link to Pubmed

Published data will be made available on request